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 Key Specifications of SPAH Step application for TamiFlu secondary production
The following are some key specifications of SPAH STEP application for TamiFlu secondary production.
- Finished dosage forms Capsules (TamiFlu)
- Annual capacity 500-600 million capsules on 5-hour of 2 shifts per 5-day work week
- Total built-up area 5,800 sq m
- Production characteristics Dispensary with sieving; Intermediate Bulk Container blending; Alcoholic granulation and drying; alu/alu and alu/pvc blister packing;
- Purified water package 500 l / hr
- R & D pilot batch manufacturing area well-embedded and integrated with the facility
- ACMV package Total 78,500 cubic metres / hr
- Production & laboratories Approx. 1,900 sq m
- Warehousing Approx. 1,200 sq m
- Office & amenities Approx. 1,200 sq m
The following cost is based on engineering and technical data of a Singapore facility by Beacons Pharmaceuticals Pte Ltd and Foster Wheeler.
SPAH 1 Cost Estimate Summary (~10%) |
Direct Material |
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Process Equipment |
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Commercial Size 4 capsule filler, 4 Blister Pack |
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8 IBC/capsule Bins+ Single pot+ fluid Bed |
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+ Granulator |
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Lab Equipment and Furniture |
$ 24,000,000 |
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Utility Equipment+ ACMV+ BMS |
$ 2,505,000 |
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Bulk Material +Commissioning Spares |
$ 1,167,000 |
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Field Construction |
$ 12,112,000 |
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Construction Indirect |
$ 475,600 |
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Main Contractor Services |
$ 2,687,000 |
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Escalation |
$ 837,800 |
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Technical Development Allowance |
$ 287,800 |
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Contingency |
$1,741,000 |
Grand Total * |
SGD $45,813,500 (~US$27 M) |
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* The Grand Total exclude the land, raw material, human resources and other operational cost. |
